Comparison
MK-677 vs Ipamorelin
Oral convenience vs injectable precision for growth hormone.
Reviewed by Dr. Sarah Mitchell, PharmD
Administration
Oral capsule/liquid
Subcutaneous injection
GH Pattern
Continuous 24h elevation
Acute pulsatile release
Half-Life
~5 hours (IGF-1 24h)
~2 hours
Appetite Increase
Significant
None
Water Retention
Common
Minimal
Insulin Resistance
Possible with long-term use
Not observed
Cortisol/Prolactin
Minimal increase
No increase
Convenience
High — oral, no needles
Moderate — requires injection
Our Verdict
MK-677 is oral and convenient with 24h GH elevation, but causes water retention, increased appetite, and potential insulin resistance. Ipamorelin is injectable but far cleaner with no side effects. Ipamorelin is preferred for long-term anti-aging use.