Setmelanotide
Also known as: Imcivree · RM-493
An FDA-approved MC4R agonist exclusively for patients with rare genetic obesity mutations (POMC, PCSK1, or LEPR deficiencies).
Reviewed by Dr. Sarah Mitchell, PharmD, BCPS
Lead Researcher · 12+ years in peptide therapeutics
~11 hours
1–3 mg daily
Subcutaneous injection
Mechanism of Action
Bypasses broken genetic satiety pathways by directly activating MC4R to restore hunger regulation in genetically obese patients.
Key Research Areas
Frequently Asked Questions
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Research Disclaimer
The information provided about Setmelanotide is for educational purposes only and is not intended as medical advice. Always consult a qualified healthcare professional before starting any peptide protocol. Products discussed have not been evaluated by the FDA unless explicitly noted.