PeptidePicker
SleepResearch

DSIP

Also known as: Delta Sleep-Inducing Peptide

A naturally occurring nonapeptide that resets circadian rhythm and forces the brain into deep slow-wave (delta) sleep. Not a sedative but a master sleep regulator.

Dr. Sarah Mitchell

Reviewed by Dr. Sarah Mitchell, PharmD, BCPS

Lead Researcher · 12+ years in peptide therapeutics

Half-Life

~7–8 minutes

Typical Dose

100–200 mcg before bed

Administration

Subcutaneous injection or intranasal

Mechanism of Action

Modulates GABAergic and glutamatergic neurotransmission, resynchronizes circadian oscillators, and reduces cortisol/ACTH to enable deep restorative sleep.

Key Research Areas

sleepcircadiandelta wavecortisolinsomnia

Frequently Asked Questions

What is DSIP?
A naturally occurring nonapeptide that resets circadian rhythm and forces the brain into deep slow-wave (delta) sleep. Not a sedative but a master sleep regulator.
How does DSIP work?
Modulates GABAergic and glutamatergic neurotransmission, resynchronizes circadian oscillators, and reduces cortisol/ACTH to enable deep restorative sleep.
What is the recommended dosage for DSIP?
The typical research dosage is 100–200 mcg before bed, administered via Subcutaneous injection or intranasal. Dosage protocols vary by study and should be determined by a qualified healthcare professional.
What is the half-life of DSIP?
The half-life of DSIP is approximately ~7–8 minutes. This affects dosing frequency and timing in research protocols.
Is DSIP FDA approved?
DSIP is currently classified as "Research" and is not FDA approved for general use. It is available for research purposes or through compounding pharmacies depending on your jurisdiction.

Research Disclaimer

The information provided about DSIP is for educational purposes only and is not intended as medical advice. Always consult a qualified healthcare professional before starting any peptide protocol. Products discussed have not been evaluated by the FDA unless explicitly noted.