Comparison
CJC-1295 vs Ipamorelin
GHRH vs GHRP — why they're almost always used together.
Reviewed by Dr. Sarah Mitchell, PharmD
Pathway
GHRH receptor (pituitary priming)
Ghrelin/GHS receptor (GH pulse)
Half-Life
~30 min (no DAC) / ~8 days (DAC)
~2 hours
GH Release Pattern
Amplifies existing pulses
Triggers acute GH spike
Side Effects
Minimal
Very minimal — cleanest GHRP
Hunger Stimulation
None
None (unlike GHRP-6)
Typical Dose
100–200 mcg
200–300 mcg
Best Timing
Before bed (with Ipamorelin)
Before bed (with CJC-1295)
Synergy
3–5x GH increase when combined
3–5x GH increase when combined
Our Verdict
These peptides work through different pathways (GHRH vs ghrelin) and are synergistic when combined. Ipamorelin is cleaner with fewer side effects; CJC-1295 extends GH elevation. Together they produce far greater GH release than either alone.