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Best Peptides for Anti-Aging

Anti-aging peptides target the fundamental mechanisms of biological aging — telomere shortening, mitochondrial decline, cellular senescence, and oxidative stress. From copper peptides that remodel skin to senolytics that clear zombie cells, this category spans the frontier of longevity science.

Dr. Sarah Mitchell

Reviewed by Dr. Sarah Mitchell, PharmD, BCPS

Lead Researcher · Updated 2026

Showing 19 peptides ranked by popularity and research evidence

1

NAD+

ResearchAnti-Aging

A coenzyme present in every living cell, critical for energy metabolism and cellular repair. NAD+ levels decline with age; replenishment is a cornerstone of modern longevity medicine.

Half-life: ~45 minutes (IV)Dose: 250–500 mg (IV) or 100–300 mg (subcutaneous)
2

Sermorelin

ResearchGrowth Hormone

A bioidentical analog of growth hormone-releasing hormone (GHRH). The bedrock of clinical anti-aging endocrinology, prescribed to safely restore youthful IGF-1 levels and improve sleep.

Half-life: ~10–20 minutesDose: 200–300 mcg before bed
3

Ipamorelin

ResearchGrowth Hormone

The cleanest growth hormone secretagogue available, delivering potent GH pulses without triggering hunger, cortisol, or prolactin spikes. The premier choice for year-round anti-aging protocols.

Half-life: ~2 hoursDose: 200–300 mcg
4

GHK-Cu

ResearchAnti-Aging

A naturally occurring copper-binding tripeptide that modulates over 4,000 human genes. The gold standard in dermal remodeling, wound healing, and systemic anti-aging research.

Half-life: ~1–2 hoursDose: 1–2 mg daily
5

CJC-1295

ResearchGrowth Hormone

A modified GHRH analog that delivers intense, acute GH spikes mimicking natural nocturnal pulses. Almost always stacked with Ipamorelin for synergistic, non-suppressive GH release.

Half-life: ~30 minutes (no DAC)Dose: 100–200 mcg
6

Epitalon

ResearchAnti-Aging

A synthetic tetrapeptide derived from the bovine pineal gland, sitting at the apex of life-extension bioscience. Studied for its ability to activate telomerase and reset the biological clock.

Half-life: ~2–4 hoursDose: 5–10 mg daily (cycled)
7

KPV

ResearchRecovery

A master anti-inflammatory tripeptide derived from alpha-MSH. Obliterates systemic inflammation at the genetic level without immunosuppression, making it a staple for IBD and gut health.

Half-life: ~30 minutesDose: 200–500 mcg
8

MOTS-c

ResearchMitochondrial

A mitochondrial-derived peptide dubbed an 'exercise mimetic' that reverses age-related insulin resistance and enhances fat oxidation even in sedentary individuals.

Half-life: ~4–6 hoursDose: 5–10 mg weekly
9

SS-31

Clinical TrialsMitochondrial

A mitochondria-targeted tetrapeptide that stabilizes the inner membrane to halt age-related energy decline. In clinical trials for heart failure and rare mitochondrial diseases.

Half-life: ~4 hoursDose: 0.25 mg/kg
10

Glutathione

ResearchAnti-Aging

The body's master antioxidant — an endogenous tripeptide critical for liver detoxification and cellular defense. Levels decline with age and toxin exposure.

Half-life: ~1.6 hoursDose: 200–600 mg (IV) or 500–1000 mg (oral/liposomal)
11

FOXO4-DRI

ResearchAnti-Aging

A senolytic peptide that selectively forces zombie (senescent) cells to self-destruct, reducing systemic inflammation and reversing aging markers.

Half-life: ~2–6 hoursDose: Varies (research protocols)
12

Humanin

ResearchAnti-Aging

A mitochondrial-derived peptide that protects against programmed cell death. Discovered in brains of Alzheimer's patients who resisted neural decay.

Half-life: ~30 minutesDose: 1–5 mg
13

Matrixyl

ResearchCosmetic

The gold standard in structural dermal remodeling. Tricks the skin into overproducing collagen by mimicking wound signals.

Half-life: ~6 hours (topical)Dose: Topical (serum formulation)
14

Thymalin

ResearchAnti-Aging

A legendary polypeptide bioregulator from Soviet military research that regenerates the involuted thymus gland and extends lifespan.

Half-life: ~30 minutesDose: 10 mg daily (10-day course)
15

SLU-PP-332

ResearchMitochondrial

A synthetic ERRγ agonist hailed as an exercise mimetic that replicates endurance training adaptations without physical exertion.

Half-life: ~4–8 hoursDose: Research dosing
16

Sermorelin + Ipamorelin

ResearchGrowth Hormone

The 'Golden Ratio' of clinical anti-aging: a GHRH + GHRP combination that produces synergistic GH release exceeding either peptide alone.

Half-life: ~10–30 min (sermorelin) / ~2 hours (ipamorelin)Dose: 100 mcg each, combined before bed
17

Decapeptide-12

ResearchCosmetic

A skin-lightening peptide that inhibits melanin production for even skin tone without the toxicity of hydroquinone.

Half-life: ~4 hours (topical)Dose: Topical (serum formulation)
18

Epithalamin

ResearchBioregulator

The natural Cytomax extraction from pineal glands, the raw predecessor to synthetic Epitalon. Used in Khavinson's landmark 15-year human longevity studies.

Half-life: ~3 hoursDose: 10 mg daily (10-day course)
19

Endoluten

ResearchBioregulator

The crown jewel of the Khavinson Cytomax line — the natural pineal extract predecessor to Epitalon for circadian and longevity restoration.

Half-life: ~30 minutesDose: Per bioregulator protocol

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